HIV-1 p24 Gag monoclonal antibody - Clone 24-2

Reagent Name

HIV-1 p24 Gag monoclonal antibody (#24-2)

 

Description

Hybridoma expressing antibodies to human immunodeficiency virus type 1

 

Immunogen

Bacterially expressed, hexahistidine amino-terminal tagged HIV-1 p24 Gag protein (clade B, HXB-3 isolate)

 

Relevance

p24 is encoded by the HIV gag gene and is an important structural component of the capsid core of the HIV particle

 

Cross reactivity

Not tested

 

Specificity

Epitope not mapped

 

Tested applications

Western blots for clade B isolates of HIV; immunofluorescence assays; immunoprecipitation assays

 

Raised in

Mouse

 

Clonality

Monoclonal

 

Isotype

IgG1, k

 

References

  1. Fouchier RA, Meyer BE, Simon JH, Fischer U, Malim MH. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import. EMBO J 16:4531-4539, 1997.
  2. Gaddis NC, Chertova E, Sheehy AM, Henderson LE, Malim MH. Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. Journal of Virology 77:5810-5820, 2003.
  3. Swanson CM, Puffer BA, Ahmad KM, Doms RW, Malim MH. Retroviral mRNA nuclear export elements regulate protein function and virion assembly. EMBO J 23:2632-2640, 2004.
Patent Information:
For Information, Contact:
Melissa Rubock
IP & Licensing Manager
King's College London
melissa.rubock@kcl.ac.uk
Inventors:
Michael Malim
Keywords: