Human Thyroglobulin Monoclonal Antibody - Clone 1D4

Research tool for

• ELISA
• Radioimmunoassay
• In vivo imaging

Thyroglobulin is a large iodinated glycoprotein which is produced by the thyroid gland, functioning as a prohormone in the synthesis of thyroxine (T4) and triiodothyronine (T3).  Levels of serum thyroglobulin are elevated in a variety of thyroid diseases, such as Grave’s disease (goiter), subacute thyroiditis and differentiated thyroid carcinoma.

Product Type

Hybridoma for monoclonal antibody

Immunogen

Purified human thyroglobulin

Cross Reactivity

Cross-reacts with baboon.  Does not cross react with sheep, pig, bovine, mouse, chicken or rabbit thyroglobulin

Specificity

Detects both native and denatured human thyroglobulin

Raised in

Mouse

Isotype

IgG₁

References

1. Shepherd PS, Lazarus CR, Mistry RD and Maisey MN. 1985.  Detection of thyroid tumour using a monoclonal 123I anti-thyroglobulin antibody.  Eur. J. Nucl. Med. 10: 291-295.
2. Chan, CTJ, Byfield, TGH, Himsowrth RL and Shepherd PS. 1987.  Human autoantibodies to thyroglobulin are directed towards a restricted number of human specific epitopes. Clin Exp. Immunol. 70: 516-523.