Mouse anti-human SERCA 3 antibody - Clone PL/IM430

Reagent Name

Mouse anti-human SERCA 3 antibody

 

Immunogen

Human platelet intracellular membranes

 

Relevance

SERCA 3 is the sarco-endoplasmic reticulum Ca2+ ATPase that sequesters Ca2+ into intracellular stores of mammalian cells. This antibody inhibits Ca2+ sequestration and Ca2+ATPase activity mediated by human SERCA3.

 

Cross reactivity

Human

 

Specificity

Epitope has recently been described to be between amino acids 1-236 of human SERCA3. PL/IM430 recognises a 100kDa SERCA3 protein in platelet lysates.

 

Tested Applications

Western blotting, immunoprecipitation, immunohistochemistry. SERCA3 function blocking antibody. Removal of sodium azide is recommended prior to functional assays.

 

Raised in

Mouse

 

Clonality

Monoclonal

 

Isotype

IgG1

 

References

  1. Hack et al. 1988 Biochm. J. 250, 355-361. Bokkala et al 1995 Biochem. J. 306, 837-842. Chandrasekera and Lytton 2003 J. Biol. Chem. 278, 12482-12488.
Patent Information:
For Information, Contact:
Salma Ishaq
IP & Licensing Manager
King's College London
salma.ishaq@kcl.ac.uk
Inventors:
Kalwant Authi
Michael Wilkinson
Keywords: