Human Thyrotrophin Receptor Monoclonal Antibody - Clone 2C11

The human thyrotrophin receptor (TSHR) is found primarily in epithelial cells of thyroid follicles where it induces (by cAMP) the phospholipase C and protein kinase A signal transduction pathways.  TSHR is the major pathogenic autoantigen in human autoimmune thyroid Graves’ disease.

 

 

Lanes

  1. TSHR
  2. Glycosylated  TSHR
  3. TSHR - GST
  4. Residues 125-369 TSHR - GST

 

Product Type

Hybridoma for monoclonal antibody


Immunogen

Bacterially expressed extracellular domain (residues 1-415 of human TSHR fused to GST)


Cross Reactivity

Cross-reacts with human and theoretically with rat, pig, sheep, mouse, dog, cat


Specificity

Detects residues 352 - 362 of human TSHR. 


Raised in

Mouse


Isotype

IgG1

 

References

  1. Shepherd PS, Da Costa CR, Cridland JC, Gilmore KS, Johnstone AP. 1999.  Monoclonal antibodies that recognize the native human thyrotrophin receptor.  Mol Cell Endocrinol. 149: 197-206.
  2. Johnstone,AP, Cridland JC, Da Costa CR, Nussy SS, Shepherd. 2003.  A functional site on the human thyrotrophin receptor – potential therapeutic target in Graves’ disease. Clin Endocrinol. 59: 437-441.
Patent Information:
For Information, Contact:
Melissa Rubock
IP & Licensing Manager
King's College London
melissa.rubock@kcl.ac.uk
Inventors:
Philip Shepherd
Keywords: