Mouse anti-human Integrin beta 3 (CD61) antibody - Clone PM6/13

Reagent Name

Human Integrin beta 3 antibody

 

Immunogen

Human platelet membranes

 

Relevance

Integrin beta 3 is also known as glycoprotein IIIa and in a complex with the integrin alpha 2b subunit forms the receptor for fibrinogen, fibronectin and von Willebrand Factor on activated platelets.  Integrin beta 3 can also complex with alpha V integrin. The antibody inhibits platelet aggregation, inhibits the binding of soluble fibrinogen to activated platelets and also inhibits adhesion of activated platelets to immobilised fibrinogen, fibronectin or vWF.

 

Cross reactivity

Human and baboon

 

Specificity

Epitope not mapped. The antibody inhibits binding of soluble fibrinogen (but not soluble fibronectin) to activated platelets.

 

Tested Applications

Flow cytometry, immunohistology, immunoprecipitation, western blotting under non-reducing conditions. Removal of sodium azide is recommended prior to functional assays.

 

Raised in

Mouse

 

Clonality

Monoclonal

 

Isotype

IgG1

 

References

  1. Patel et al 1998 Thromb. Haemos. 79, 177-185; Lu et al 1994 Biochem. J. 304, 929-936.
Patent Information:
For Information, Contact:
Salma Ishaq
IP & Licensing Manager
King's College London
salma.ishaq@kcl.ac.uk
Inventors:
Kalwant Authi
Michael Wilkinson
Keywords: