Search Results - Diagnostics

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Assay for predicting conversion to Alzheimer's Disease and Monitoring disease progression
An in vitro assay of human hippocampal neurogenesis (HN) which utilises an established human hippocampal progenitor cell line and patients’ human serum to provide prediction of progression from mild cognitive impairment (MCI) to Alzheimer’s Disease (AD) and helps distinguish those individuals diagnosed with MCI who will or will not deve...
Published: 24/03/2017   |   Inventor(s): Sandrine Thuret, Jack Price, Aleksandra Maruszak, Tytus Murphy, Simon Lovestone
Keywords(s):  
Category(s): Diagnostics
Detection of early stage heart failure – 1st Phase Ejection Fraction (EF1)
An accurate test for detecting patients with abnormal left ventricle function in early heart failure when ejection fraction is preserved. This could prove an invaluable tool for the early diagnosis and improved prognosis of patients with heart failure. IntroductionHeart failure (HF) is a syndrome that occurs as a result of abnormal function of the ...
Published: 17/02/2017   |   Inventor(s): Philip Chowienczyk, Haotian Gu
Keywords(s):  
Category(s): Diagnostics
MR Elastography (MRE) for non-invasive diagnosis, staging and monitoring of cancer and fibrosis
Summary The detection of pathological tissue alterations by manual palpation is a simple but essential diagnostic tool used by clinicians. The "virtual palpation" of tissue has now become feasible using Magnetic Resonance Elastography (MRE). Researchers at King’s College London have developed novel MRE units that work alongside s...
Published: 17/02/2017   |   Inventor(s): Ralph Sinkus, Ondrej Holub, Simon Lambert, Rachel Clough
Keywords(s):  
Category(s): Medical devices, Diagnostics
Reducing Artifacts in Gradient-Echo MRI using Novel Radiofrequency Pulses
ProblemGradient-echo magnetic resonance imaging (MRI) is used extensively to reveal the structure, and measure the function, of different areas of the body. One particularly exciting application is functional MRI, which can be used to produce maps of brain activity in a subject performing a mental task. Unfortunately signal dropout, caused by dif...
Published: 20/05/2015   |   Inventor(s): Stephen Wastling, Gareth Barker
Keywords(s):  
Category(s): Medical devices, Diagnostics
Predictive Marker for Pre-Term Birth
A small antimicrobial peptide (elafin) predicts risk of developing a short cervix and spontaneous pre-term birth (sPTB) relatively early pregnancy (~ 12-14 weeks of pregnancy)Elevated elafin concentrations in cervico-vaginal fluid (CVF) ) predict cervical shortening from 14 weeks’ and remain high when cervical shortening is first detected. R...
Published: 15/05/2015   |   Inventor(s): Rachel Tribe
Keywords(s):  
Category(s): Diagnostics
Pentraxin 3 (PTX3) oxidation state as Prognosis Marker for Sepsis
Technology Overview:A global, unbiased, cardiac tissue-based proteomics approach for biomarker discovery in a mouse model of sepsis identified pentraxin 3 (PTX-3) as one of the most differentially expressed proteins in cardiac tissue from septic mice. PTX-3 accumulated as an octamer due to disulphide-bond formation, most notably in heart, aorta, ki...
Published: 27/08/2014   |   Inventor(s): Manuel Mayr, Friederike Cuello
Keywords(s):  
Category(s): Diagnostics
Cardiac Myosin Binding Protein C (MyC): Diagnostic Marker of Cardiac Injury
Technology Overview:Elevated levels of Cardiac troponins (cTn) reflect the occurrence of cardiac muscle necrosis and have emerged as the gold standard biomarker and are incorporated into the universal definition of acute myocardial infarction (AMI) Prof Marber's group has identified a cardiac specific biomarker, cardiac myosin-binding protein C (My...
Published: 27/08/2014   |   Inventor(s): Michael Marber, Manuel Mayr, Sebastien Jacquet, Mathias Gautel
Keywords(s):  
Category(s): Diagnostics
Non-Ionising Imaging
Technology OverviewThe technology uses light at a given near infrared wavelength [NIR] to create a transmission image of dental caries (decay). Healthy hard tissues (enamel, dentine and cementum) tend to ‘guide’ light of this wavelength, leading to a bright image, whereas decay and other inhomogeneities cause optical scattering. This pr...
Published: 05/08/2014   |   Inventor(s): Christopher Longbottom, John Girkin, Simon Poland
Keywords(s):  
Category(s): Medical devices, Diagnostics
Method to identify bioburden in a root canal following preparation
The ProblemBacteria remaining in the root canal (RC) space at the time of completion of a root canal treatment (RCT) can lead to a persistent or secondary infection, which requires revision of the treatment. Currently, there are no methods in widespread use to detect bacterial presence within the root canal space in a fast and reliable manner. Suc...
Published: 21/07/2014   |   Inventor(s): Frederic Festy, Timothy Watson, Federico Foschi, Richard Cook, Garrit Koller, Francesco Mannocci
Keywords(s):  
Category(s): Medical devices, Diagnostics
Candidalysin: Anti-fungal target and immunotherapeutic candidate
The Problem Candida albicans is an opportunistic fungal pathogen, which normally exists as a commensal of the oral cavity and gastrointestinal tracts and frequently causes of superficial vaginitis infections. Moreover, common clinical procedures, such as gastrointestinal surgery, implantation of a central venous catheter or ant...
Published: 04/07/2014   |   Inventor(s): Julian Naglik, Bernhard Hube, David Moyes, Sarah Höfs, Duncan Wilson, Shirley Tang, Jonathan Richardson
Keywords(s):  
Category(s): Diagnostics, Therapeutics