Search Results - Diagnostics

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Nanoparticles suitable for multiple imaging modalities
ProblemMedical imaging plays an increasingly important role not only in disease diagnosis but also in monitoring the therapeutic treatment. The principal medical imaging modalities include magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission commuted tomography (SPECT), and optical imaging (OI). However, ea...
Published: 13/06/2017   |   Inventor(s): Xianjin Cui, Mark Green, Philip Blower
Keywords(s):  
Category(s): Diagnostics, Therapeutics, Research Tools - Imaging
Imaging of Unstable Atherosclerotic Plaque via a Novel Magnetic Resonance (MR) Contrast Agent
The ProblemHeart attack (acute myocardial infarction) is predominantly caused by plaque in blood vessels rupturing or eroding. Biological processes found to be associated with plaque progression and destabilization are inflammation, outward vessel wall remodelling and dysfunctional matrix synthesis and degradation. The majority of plaques causing...
Published: 13/06/2017   |   Inventor(s): Rene Botnar, Alkystis Phinikaridou
Keywords(s):  
Category(s): Diagnostics, Medical devices
Detection of early stage Vascular Calcification
SummaryA non-invasive and inexpensive assay for detection and diagnosis of early vascular calcification (VC). Specific components of the patient’s blood are isolated and analysed for molecular markers indicative of early-stage VC. A clinical calcification risk and progression score can then be calculated, thus facilitating early detection...
Published: 13/06/2017   |   Inventor(s): Catherine Shanahan, Aleksandr Kapustin
Keywords(s):  
Category(s): Diagnostics
Assay for predicting conversion to Alzheimer's Disease and Monitoring disease progression
An in vitro assay of human hippocampal neurogenesis (HN) which utilises an established human hippocampal progenitor cell line and patients’ human serum to provide prediction of progression from mild cognitive impairment (MCI) to Alzheimer’s Disease (AD) and helps distinguish those individuals diagnosed with MCI who will or will not deve...
Published: 24/03/2017   |   Inventor(s): Sandrine Thuret, Jack Price, Aleksandra Maruszak, Tytus Murphy, Simon Lovestone
Keywords(s):  
Category(s): Diagnostics
Detection of early stage heart failure – 1st Phase Ejection Fraction (EF1)
An accurate test for detecting patients with abnormal left ventricle function in early heart failure when ejection fraction is preserved. This could prove an invaluable tool for the early diagnosis and improved prognosis of patients with heart failure. IntroductionHeart failure (HF) is a syndrome that occurs as a result of abnormal function of the ...
Published: 17/02/2017   |   Inventor(s): Philip Chowienczyk, Haotian Gu
Keywords(s):  
Category(s): Diagnostics
MR Elastography (MRE) for non-invasive assessment of cancer and fibrosis
Summary The detection of pathological tissue alterations by manual palpation is a simple but essential diagnostic tool. Recently, the virtual “palpation” of tissue has become feasible using Magnetic Resonance Elastography (MRE). Researchers at King’s College London have invented novel MRE units that work alongside standard MRI ...
Published: 17/02/2017   |   Inventor(s): Ralph Sinkus, Ondrej Holub, Simon Lambert, Rachel Clough
Keywords(s):  
Category(s): Medical devices, Diagnostics
Reducing Artifacts in Gradient-Echo MRI using Novel Radiofrequency Pulses
ProblemGradient-echo magnetic resonance imaging (MRI) is used extensively to reveal the structure, and measure the function, of different areas of the body. One particularly exciting application is functional MRI, which can be used to produce maps of brain activity in a subject performing a mental task. Unfortunately signal dropout, caused by dif...
Published: 20/05/2015   |   Inventor(s): Stephen Wastling, Gareth Barker
Keywords(s):  
Category(s): Medical devices, Diagnostics
Predictive Marker for Pre-Term Birth
A small antimicrobial peptide (elafin) predicts risk of developing a short cervix and spontaneous pre-term birth (sPTB) relatively early pregnancy (~ 12-14 weeks of pregnancy)Elevated elafin concentrations in cervico-vaginal fluid (CVF) ) predict cervical shortening from 14 weeks’ and remain high when cervical shortening is first detected. R...
Published: 15/05/2015   |   Inventor(s): Rachel Tribe
Keywords(s):  
Category(s): Diagnostics
Pentraxin 3 (PTX3) oxidation state as Prognosis Marker for Sepsis
Technology Overview:A global, unbiased, cardiac tissue-based proteomics approach for biomarker discovery in a mouse model of sepsis identified pentraxin 3 (PTX-3) as one of the most differentially expressed proteins in cardiac tissue from septic mice. PTX-3 accumulated as an octamer due to disulphide-bond formation, most notably in heart, aorta, ki...
Published: 27/08/2014   |   Inventor(s): Manuel Mayr, Friederike Cuello
Keywords(s):  
Category(s): Diagnostics
Cardiac Myosin Binding Protein C (MyC): Diagnostic Marker of Cardiac Injury
Technology Overview:Elevated levels of Cardiac troponins (cTn) reflect the occurrence of cardiac muscle necrosis and have emerged as the gold standard biomarker and are incorporated into the universal definition of acute myocardial infarction (AMI) Prof Marber's group has identified a cardiac specific biomarker, cardiac myosin-binding protein C (My...
Published: 27/08/2014   |   Inventor(s): Michael Marber, Manuel Mayr, Sebastien Jacquet, Mathias Gautel
Keywords(s):  
Category(s): Diagnostics
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